{"id":572,"date":"2020-02-17T11:21:50","date_gmt":"2020-02-17T10:21:50","guid":{"rendered":"https:\/\/www.sunrockbiopharma.com\/ccr9\/"},"modified":"2024-04-09T09:51:44","modified_gmt":"2024-04-09T07:51:44","slug":"ccr9","status":"publish","type":"page","link":"https:\/\/www.sunrockbiopharma.com\/es\/ccr9\/","title":{"rendered":"CCR9"},"content":{"rendered":"<p>[vc_row][vc_column css_animation=\u00bbfadeInUp\u00bb el_class=\u00bbbox-shadow\u00bb][vc_column_text]<\/p>\n<h2>Diana CCR9<\/h2>\n<p>[\/vc_column_text][vc_column_text]Las citoquinas quimiot\u00e1cticas o quimioquinas se unen a receptores acoplados a prote\u00edna G y median m\u00faltiples funciones biol\u00f3gicas, entre ellas la adhesi\u00f3n y extravasaci\u00f3n de leucocitos. Existe una fuerte asociaci\u00f3n entre la expresi\u00f3n en c\u00e9lulas tumorales de ciertos receptores de quimioquinas y el progreso del c\u00e1ncer, desarrollo de met\u00e1stasis y mal pron\u00f3stico.<\/p>\n<p>El receptor de quimioquinas 9, CCR9, se expresa de forma natural en el timo y las criptas del intestino delgado.<\/p>\n<p>Se ha demostrado que la expresi\u00f3n de CCR9 se asocia con una recurrencia temprana y un aumento de la capacidad metast\u00e1tica en tumores s\u00f3lidos como c\u00e1ncer de p\u00e1ncreas y de ovario.<\/p>\n<p>Por otro lado, en tumores hematol\u00f3gicos como la leucemia linfobl\u00e1stica aguda de c\u00e9lulas T (T-ALL), CCR9 se encuentra sobreexpresado y se asocia con un aumento del potencial metast\u00e1sico y la quimiorresistencia de los tumores.[\/vc_column_text][\/vc_column][\/vc_row][vc_row foundry_padding=\u00bbpt0&#8243;][vc_column css_animation=\u00bbfadeInLeft\u00bb][vc_column_text]<\/p>\n<h3>Programa CCR9. Evidencia cient\u00edfica<\/h3>\n<p>[\/vc_column_text][\/vc_column][vc_column css_animation=\u00bbfadeInUp\u00bb el_class=\u00bblista\u00bb][vc_column_text el_class=\u00bblista\u00bb]<\/p>\n<ul>\n<li>\n<h4>CCR9 como diana terap\u00e9utica en tumores s\u00f3lidos<\/h4>\n<ul>\n<li>CCR9 es una diana inmuno-oncol\u00f3gica prometedora en diferentes tumores s\u00f3lidos, como el c\u00e1ncer de p\u00e1ncreas y de ovario.<\/li>\n<li>La sobreexpresi\u00f3n de CCR9 se asocia con estadios metast\u00e1ticos de c\u00e1ncer de p\u00e1ncreas.<\/li>\n<li>SunRock ha demostrado que la sobreexpresi\u00f3n de CCR9 soluble est\u00e1 asociada a ciertos tumores s\u00f3lidos en etapas invasivas en pacientes de c\u00e1ncer de mama, pulm\u00f3n y ovario.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text el_class=\u00bblista\u00bb]<\/p>\n<ul>\n<li>\n<h4>CCR9 se sobreexpresa en neoplasias sangu\u00edneas<\/h4>\n<ul>\n<li>El an\u00e1lisis en muestras de sangre o de m\u00e9dula \u00f3sea de pacientes con distintos tipos de tumores hematol\u00f3gicos (como T-ALL y linfoma no Hodgkin) ha demostrado que CCR9 se encuentra sobreexpresado en hasta el 80% de los pacientes.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row foundry_padding=\u00bbpt0 pb0&#8243;][vc_column css_animation=\u00bbfadeInLeft\u00bb][vc_column_text]<\/p>\n<h2>Anticuerpos terap\u00e9uticos anti-CCR9<\/h2>\n<p>[\/vc_column_text][\/vc_column][vc_column css_animation=\u00bbfadeInUp\u00bb][vc_column_text]<\/p>\n<p style=\"background: white; margin: 0cm 0cm 18.0pt 0cm;\"><span style=\"font-family: 'IBM Plex Sans',sans-serif; color: #070f26;\">SunRock, en colaboraci\u00f3n con CSIC, ha desarrollado anticuerpos novedosos anti-CCR9 que reconocen un ep\u00edtopo exclusivo y con actividad antitumoral mediada por ADCC y CDC. Estos anticuerpos han demostrado su eficacia y seguridad tanto en modelos <i>in vitro<\/i> como <i>in vivo<\/i>.<\/span><\/p>\n<p style=\"background: white; margin: 0cm 0cm 18.0pt 0cm;\"><span style=\"font-family: 'IBM Plex Sans',sans-serif; color: #070f26;\">Los tumores de ratones tratados con anticuerpos anti-CCR9 mostraron un aumento de la apoptosis y la necrosis y una reducci\u00f3n de la angiog\u00e9nesis y la proliferaci\u00f3n celular (Chamorro et al. 2014; Somovilla-Crespo et al. 2018).<\/span><\/p>\n<p style=\"margin-top: 0cm; background: white;\"><span style=\"font-family: 'IBM Plex Sans',sans-serif; color: #070f26;\">SunRock Biopharma posee los derechos globales y exclusivos de la propiedad intelectual que protege los anticuerpos dirigidos contra CCR9.<\/span><\/p>\n<p>[\/vc_column_text][vc_tta_tour style=\u00bbflat\u00bb shape=\u00bbsquare\u00bb color=\u00bbwhite\u00bb active_section=\u00bb1&#8243; el_class=\u00bbtour-anti\u00bb][vc_tta_section title=\u00bbSRB1&#8243; tab_id=\u00bb1582107529302-90b36921-4902&#8243;][vc_column_text el_class=\u00bblista\u00bb]SRB1 es un anticuerpo anti-CCR9\u00a0<em>first-in-class<\/em> que ha demostrado una elevada eficacia para tratar el c\u00e1ncer de p\u00e1ncreas y leucemia linfobl\u00e1stica aguda de c\u00e9lulas T en modelos precl\u00ednicos.<\/p>\n<ul>\n<li>\n<h4>SRB1 ha demostrado eficacia <em>in vivo<\/em>: c\u00e1ncer de p\u00e1ncreas<\/h4>\n<ul>\n<li>Regresi\u00f3n tumoral completa en modelos animales humanizados en los que se implantaron tumores derivados de pacientes con c\u00e1ncer de p\u00e1ncreas<\/li>\n<li>Eficacia terap\u00e9utica mejorada respecto a los tratamientos quimioter\u00e1picos convencionales y pembrolizumab<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<h4>SRB1 ha demostrado eficacia <em>in vivo<\/em>: modelo de c\u00e9lulas circulantes T-ALL<\/h4>\n<ul>\n<li>Regresi\u00f3n tumoral completa en modelos ortot\u00f3picos de T-ALL<\/li>\n<li>Eficacia terap\u00e9utica mejorada respecto a los tratamientos quimioter\u00e1picos convencionales<\/li>\n<li>No se observaron s\u00edntomas de toxicidad en los modelos animales analizados<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][\/vc_tta_tour][\/vc_column][\/vc_row][vc_row css_animation=\u00bbfadeInUp\u00bb el_class=\u00bbfirst-section\u00bb][vc_column el_class=\u00bbbox-shadow\u00bb][vc_column_text]<\/p>\n<h2>Anti-CCR9 Pipeline<\/h2>\n<p>[\/vc_column_text][vc_row_inner][vc_column_inner width=\u00bb1\/6&#8243;][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/6&#8243;][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=\u00bb1\/6&#8243;][vc_empty_space height=\u00bb65px\u00bb][vc_empty_space height=\u00bb20px\u00bb][vc_column_text]<\/p>\n<h5>SRB1 (tumores hematol\u00f3gicos)<\/h5>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/6&#8243;][vc_column_text]<\/p>\n<p style=\"text-align: left;\"><strong>Descubrimiento<\/strong><\/p>\n<p>[\/vc_column_text][vc_separator border_width=\u00bb4&#8243;][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Descubrimiento%22%2C%22value%22%3A%22100%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_empty_space height=\u00bb59px\u00bb][vc_separator color=\u00bbcustom\u00bb border_width=\u00bb4&#8243; accent_color=\u00bb#45509a\u00bb][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22in%20vitro%22%2C%22value%22%3A%22100%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb el_class=\u00bbem\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_column_text]<\/p>\n<p style=\"text-align: center;\"><strong>Precl\u00ednica<\/strong><\/p>\n<p>[\/vc_column_text][vc_separator color=\u00bbcustom\u00bb border_width=\u00bb4&#8243; accent_color=\u00bb#45509a\u00bb][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22in%20vivo%22%2C%22value%22%3A%22100%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb el_class=\u00bbem\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_empty_space height=\u00bb59px\u00bb][vc_separator color=\u00bbcustom\u00bb border_width=\u00bb4&#8243; accent_color=\u00bb#45509a\u00bb][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Regulatoria%22%2C%22value%22%3A%2250%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_empty_space height=\u00bb59px\u00bb][vc_separator color=\u00bbcustom\u00bb border_width=\u00bb4&#8243; accent_color=\u00bb#e0bf3d\u00bb][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Fase%20I%22%2C%22value%22%3A%220%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_column_text]<\/p>\n<p style=\"text-align: center;\"><strong style=\"white-space: nowrap;\">Fases cl\u00ednicas<\/strong><\/p>\n<p>[\/vc_column_text][vc_separator color=\u00bbcustom\u00bb border_width=\u00bb4&#8243; accent_color=\u00bb#e0bf3d\u00bb][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Fase%20II%22%2C%22value%22%3A%220%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_empty_space height=\u00bb59px\u00bb][vc_separator color=\u00bbcustom\u00bb border_width=\u00bb4&#8243; accent_color=\u00bb#e0bf3d\u00bb][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Fase%20III%22%2C%22value%22%3A%220%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=\u00bb1\/6&#8243;][vc_column_text]<\/p>\n<h5>SRB1 (tumores s\u00f3lidos)<\/h5>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/6&#8243;][vc_column_text el_class=\u00bbvisible-xs visible-sm\u00bb]<strong>Descubrimiento<\/strong>[\/vc_column_text][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Descubrimiento%22%2C%22value%22%3A%22100%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_column_text el_class=\u00bbvisible-xs visible-sm\u00bb]<strong>Precl\u00ednica<\/strong>[\/vc_column_text][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22in%20vitro%22%2C%22value%22%3A%22100%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb el_class=\u00bbem\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22in%20vivo%22%2C%22value%22%3A%22100%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb el_class=\u00bbem\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Regulatoria%22%2C%22value%22%3A%2250%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_column_text el_class=\u00bbvisible-xs visible-sm\u00bb]<strong style=\"white-space: nowrap;\">Fases cl\u00ednicas<\/strong>[\/vc_column_text][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Fase%20I%22%2C%22value%22%3A%220%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Fase%20II%22%2C%22value%22%3A%220%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][vc_column_inner el_class=\u00bbcol-md-custom\u00bb width=\u00bb1\/12&#8243;][vc_progress_bar values=\u00bb%5B%7B%22label%22%3A%22Fase%20III%22%2C%22value%22%3A%220%22%7D%5D\u00bb bgcolor=\u00bbcustom\u00bb custombgcolor=\u00bb#ffce1c\u00bb][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column css_animation=\u00bbfadeInUp\u00bb el_class=\u00bbbox-shadow\u00bb][vc_column_text] Diana CCR9 [\/vc_column_text][vc_column_text]Las citoquinas quimiot\u00e1cticas o quimioquinas se unen a receptores acoplados a prote\u00edna G y median m\u00faltiples&#8230;<\/p>\n","protected":false},"author":1,"featured_media":573,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>SunRock Biopharma | CCR9<\/title>\r\n<meta name=\"description\" content=\"CCR9 significa Receptor de Citoquinas Quimiot\u00e1cticas 9. Las citoquinas quimiot\u00e1cticas o quimioquinas se unen a receptores acoplados a prote\u00edna G y median m\u00faltiples funciones biol\u00f3gicas, entre ellas la adhesi\u00f3n y extravasaci\u00f3n de leucocitos\" \/>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.sunrockbiopharma.com\/es\/ccr9\/\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"SunRock Biopharma | CCR9\" \/>\r\n<meta property=\"og:description\" content=\"CCR9 significa Receptor de Citoquinas Quimiot\u00e1cticas 9. 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Las citoquinas quimiot\u00e1cticas o quimioquinas se unen a receptores acoplados a prote\u00edna G y median m\u00faltiples funciones biol\u00f3gicas, entre ellas la adhesi\u00f3n y extravasaci\u00f3n de leucocitos\" \/>\r\n<meta name=\"twitter:image\" content=\"https:\/\/www.sunrockbiopharma.com\/wp-content\/uploads\/2020\/09\/sunrock-seo-tw.png\" \/>\r\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutos\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.sunrockbiopharma.com\/#organization\",\"name\":\"SunRock Biopharma\",\"url\":\"https:\/\/www.sunrockbiopharma.com\/\",\"sameAs\":[],\"logo\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.sunrockbiopharma.com\/#logo\",\"inLanguage\":\"es\",\"url\":\"https:\/\/www.sunrockbiopharma.com\/wp-content\/uploads\/2020\/09\/sunrock-seo-fb.png\",\"contentUrl\":\"https:\/\/www.sunrockbiopharma.com\/wp-content\/uploads\/2020\/09\/sunrock-seo-fb.png\",\"width\":1201,\"height\":631,\"caption\":\"SunRock Biopharma\"},\"image\":{\"@id\":\"https:\/\/www.sunrockbiopharma.com\/#logo\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.sunrockbiopharma.com\/#website\",\"url\":\"https:\/\/www.sunrockbiopharma.com\/\",\"name\":\"SunRock Biopharma\",\"description\":\"Solutions for cancer therapy\",\"publisher\":{\"@id\":\"https:\/\/www.sunrockbiopharma.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.sunrockbiopharma.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.sunrockbiopharma.com\/es\/ccr9\/#primaryimage\",\"inLanguage\":\"es\",\"url\":\"https:\/\/www.sunrockbiopharma.com\/wp-content\/uploads\/2020\/09\/sunrock-seo-fb.png\",\"contentUrl\":\"https:\/\/www.sunrockbiopharma.com\/wp-content\/uploads\/2020\/09\/sunrock-seo-fb.png\",\"width\":1201,\"height\":631,\"caption\":\"sunrock\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.sunrockbiopharma.com\/es\/ccr9\/#webpage\",\"url\":\"https:\/\/www.sunrockbiopharma.com\/es\/ccr9\/\",\"name\":\"SunRock Biopharma | CCR9\",\"isPartOf\":{\"@id\":\"https:\/\/www.sunrockbiopharma.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.sunrockbiopharma.com\/es\/ccr9\/#primaryimage\"},\"datePublished\":\"2020-02-17T10:21:50+00:00\",\"dateModified\":\"2024-04-09T07:51:44+00:00\",\"description\":\"CCR9 significa Receptor de Citoquinas Quimiot\\u00e1cticas 9. 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